Antidiabetic effect of Melicope glabra¬ (Blume) T. G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components

Melicope glabra­ (Blume) T. G. Hartley is a plant of Rutaceae family. The present study aimed to evaluate the in vivo hypoglycemic effect M. glabra leaves extract on diabetic rats and identify its bioactive components. induction diabetes Sprague-Dawley was done by combination high-fat diet low-dose streptozotocin injection. extracts standard sitagliptin were orally administered once daily for 28 days. showed drastic weight loss, hyperglycemia, poor glucose tolerance, hyperlipidemia, disturbances liver kidney functions. However, oral administration significantly lowered DPP-4 level increased glucagon-like peptide-1 (GLP-1) level. Scopoletin, pachypodol, stigmasterol revealed as active α-amylase inhibitors. This novel findings which suggest